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While the upfront price of these drugs is high, they may save money in the long run by reducing the prevalence of obesity-related diseases, such as diabetes and heart disease, which are much more costly to treat

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Neurons innervating the striatum, including dopaminergic neurons from the SNcVTA regions, take up AA, which, in low-TH-expressing cells, the phenotype can switch to a dopaminergic one through TH synthesis